Ashwagandha: an herb from India with a history of use of over 3000 years. Ashwagandha seems to be a reliable anxiolytic (anxiety reducer). Ashwagandha may also increase aspects of attention, but there’s only preliminary evidence here. Ashwagandha’s mechanism of action isn’t entirely clear. Ashwagandha seems to have GABA-mimetic activity, which may account for its anxiolytic effects. Withaferin A, a major active constituent, seems to be a fairly powerful anti-inflammatory agent. Ashwagandha is a promising anxiety reducer.